Publications

Agency Is Frame-Dependent
David Abel
Andre Barreto
Michael Bowling
Will Dabney
Shi Dong
Steven Stenberg Hansen
Anna Harutyunyan
Clare Lyle
Georgios Piliouras
Jonathan Richens
Mark Rowland
Tom Schaul
Satinder Singh
Agency is a system's capacity to steer outcomes toward a goal, and is a central topic of study across biology, philosophy, cognitive science… (see more), and artificial intelligence. Determining if a system exhibits agency is a notoriously difficult question: Dennett (1989), for instance, highlights the puzzle of determining which principles can decide whether a rock, a thermostat, or a robot each possess agency. We here address this puzzle from the viewpoint of reinforcement learning by arguing that agency is fundamentally frame-dependent: Any measurement of a system's agency must be made relative to a reference frame. We support this claim by presenting a philosophical argument that each of the essential properties of agency proposed by Barandiaran et al. (2009) and Moreno (2018) are themselves frame-dependent. We conclude that any basic science of agency requires frame-dependence, and discuss the implications of this claim for reinforcement learning.
Tackling the Problem of Distributional Shifts: Correcting Misspecified, High-Dimensional Data-Driven Priors for Inverse Problems
Bayesian inference for inverse problems hinges critically on the choice of priors. In the absence of specific prior information, population-… (see more)level distributions can serve as effective priors for parameters of interest. With the advent of machine learning, the use of data-driven population-level distributions (encoded, e.g., in a trained deep neural network) as priors is emerging as an appealing alternative to simple parametric priors in a variety of inverse problems. However, in many astrophysical applications, it is often difficult or even impossible to acquire independent and identically distributed samples from the underlying data-generating process of interest to train these models. In these cases, corrupted data or a surrogate, e.g. a simulator, is often used to produce training samples, meaning that there is a risk of obtaining misspecified priors. This, in turn, can bias the inferred posteriors in ways that are difficult to quantify, which limits the potential applicability of these models in real-world scenarios. In this work, we propose addressing this issue by iteratively updating the population-level distributions by retraining the model with posterior samples from different sets of observations and showcase the potential of this method on the problem of background image reconstruction in strong gravitational lensing when score-based models are used as data-driven priors. We show that starting from a misspecified prior distribution, the updated distribution becomes progressively closer to the underlying population-level distribution, and the resulting posterior samples exhibit reduced bias after several updates.
Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering
Yunji Liao
Hang Ma
Zhenyu Wang
Shusheng Wang
Yang He
Yunsong Chang
Huifang Zong
Haoneng Tang
Lei Wang
Yong Ke
Ping Li
Yunsheng Yuan
Aleksandra Drelich
Bi-Hung Peng
Jason Hsu
Vivian Tat
Chien-Te K. Tseng
Jingjing Song … (see 22 more)
Yunsheng Yuan
Mingyuan Wu
Junjun Liu
Yali Yue
Xiaoju Zhang
Ziqi Wang
Yang He
Jing Li
Xiaodan Ni
Hongshi Li
Yuning Xiang
Yanlin Bian
Baohong Zhang
Haiyang Yin
Dimiter S. Dimitrov
John Gilly
Lei Han
Hua Jiang
Yueqing Xie
Jianwei Zhu
Yueqing Xie
Jianwei Zhu
The rapid evolution of the viral genome has led to the continual generation of new variants of SARS-CoV-2. Developing antibody drugs with br… (see more)oad-spectrum and high efficiency is a long-term task. It is promising but challenging to develop therapeutic neutralizing antibodies (nAbs) through in vitro evolution based on antigen–antibody binding interactions. From an early B cell antibody repertoire, we isolated antibody 8G3 that retains its nonregressive neutralizing activity against Omicron BA.1 and various other strains in vitro. 8G3 protected ACE2 transgenic mice from BA.1 and WA1/2020 virus infection without adverse clinical manifestations and completely cleared viral load in the lungs. Similar to most IGHV3–53 antibodies, the binding sites of 8G3 and ACE2 largely overlap, enabling competition with ACE2 for binding to RBD. By comprehensively considering the binding free energy changes of the antigen–antibody complexes, the biological environment of their interactions, and the evolutionary direction of the antibodies, we were able to select 50 mutants. Among them, 11 were validated by experiments showing better neutralizing activities. Further, a combination of four mutations were identified in 8G3 that increased its neutralization potency against JN.1, the latest Omicron mutant, by approximately 1,500-fold, and one of the mutations led to an improvement in activity against multiple variants to a certain extent. Together, we established a procedure of rapid selection of neutralizing antibodies with potent SARS-CoV-2 neutralization activity. Our results provide a reference for engineering neutralizing antibodies against future SARS-CoV-2 variants and even other pandemic viruses.
Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering
Yunji Liao
Hang Ma
Zhenyu Wang
Shusheng Wang
Yang He
Yunsong Chang
Huifang Zong
Haoneng Tang
Lei Wang
Yong Ke
Ping Li
Yunsheng Yuan
Aleksandra Drelich
Bi-Hung Peng
Jason Hsu
Vivian Tat
Chien-Te K. Tseng
Jingjing Song … (see 20 more)
Yunsheng Yuan
Mingyuan Wu
Junjun Liu
Yali Yue
Xiaoju Zhang
Ziqi Wang
Yang He
Jing Li
Xiaodan Ni
Hongshi Li
Yuning Xiang
Yanlin Bian
Baohong Zhang
Haiyang Yin
Dimiter S. Dimitrov
John Gilly
Lei Han
Hua Jiang
Yueqing Xie
Jianwei Zhu
Owing to the ongoing mutation of SARS-CoV-2, the vast majority of therapeutic antibodies developed in the early stages have lost their neutr… (see more)alizing effects. Here, we have developed neutralizing antibodies, including 8G3 isolated from patients infected with the wild-type SARS-CoV-2 and its mutants from computational rational design. Following the mutations of 8G3 through computational technology, the neutralizing activity of the antibody was enhanced by approximately 1,500-fold. Our experimental results offer a case study for the optimization of neutralizing antibodies against SARS-CoV-2 guided by computational technology.
Temporally-Consistent Surface Reconstruction using Metrically-Consistent\n Atlases
Jan Bednařík
Vladimir G. Kim
Siddhartha Chaudhuri
Shaifali Parashar
Mathieu Salzmann
Pascal Fua
We propose a method for unsupervised reconstruction of a\ntemporally-consistent sequence of surfaces from a sequence of time-evolving\npoint… (see more) clouds. It yields dense and semantically meaningful correspondences\nbetween frames. We represent the reconstructed surfaces as atlases computed by\na neural network, which enables us to establish correspondences between frames.\nThe key to making these correspondences semantically meaningful is to guarantee\nthat the metric tensors computed at corresponding points are as similar as\npossible. We have devised an optimization strategy that makes our method robust\nto noise and global motions, without a priori correspondences or pre-alignment\nsteps. As a result, our approach outperforms state-of-the-art ones on several\nchallenging datasets. The code is available at\nhttps://github.com/bednarikjan/temporally_coherent_surface_reconstruction.\n
Bridging Causality, Individual Fairness, and Adversarial Robustness in the Absence of Structural Causal Model
Ahmad Reza Ehyaei
Samira Samadi
Despite the essential need for comprehensive considerations in responsible AI, factors such as robustness, fairness, and causality are often… (see more) studied in isolation. Adversarial perturbation, used to identify vulnerabilities in models, and individual fairness, aiming for equitable treatment of similar individuals, despite initial differences, both depend on metrics to generate comparable input data instances. Previous attempts to define such joint metrics often lack general assumptions about data and were unable to reflect counterfactual proximity. To address this, our paper introduces a \emph{causal fair metric} formulated based on causal structures encompassing sensitive attributes and protected causal perturbation. To enhance the practicality of our metric, we propose metric learning as a method for metric estimation and deployment in real-world problems in the absence of structural causal models. We also demonstrate the applications of the causal fair metric in classifiers. Empirical evaluation of real-world and synthetic datasets illustrates the effectiveness of our proposed metric in achieving an accurate classifier with fairness, resilience to adversarial perturbations, and a nuanced understanding of causal relationships.
Adapting Perioperative Care for Neurodivergent Children - A Scoping Review
Spandana Veeravalli
Maia Michaud
Judy Colton
Brenda Bourdeau
Samantha Sacks
Lindsay Hales
Elena Guadagno
AIoT Smart Home via Autonomous LLM Agents
Dmitriy Rivkin
Francois Hogan
Amal Feriani
Adam Sigal
Xue Liu
Application of deep reinforcement learning for intrusion detection in Internet of Things: A systematic review
Saeid Jamshidi
Amin Nikanjam
Kawser Wazed Nafi
Rasoul Rasta
Isolating the impact of tissue heterogeneities in high dose rate brachytherapy treatment of the breast
Jules Faucher
Vincent Turgeon
Boris Bahoric
S. Enger
Peter G.F. Watson
Programmable Shape‐Preserving Soft Robotics Arm via Multimodal Multistability (Adv. Funct. Mater. 6/2025)
Benyamin Shahryari
Hossein Mofatteh
Armin Mirabolghasemi
Abdolhamid Akbarzadeh
A Scalable Architecture for Future Regenerative Satellite Payloads
Olfa Ben Yahia
Zineb Garroussi
Brunilde Sansò
Jean-François Frigon
Stéphane Martel
Gunes Karabulut Kurt
This paper addresses the limitations of current satellite payload architectures, which are predominantly hardware-driven and lack the flexib… (see more)ility to adapt to increasing data demands and uneven traffic. To overcome these challenges, we present a novel architecture for future regenerative and programmable satellite payloads and utilize interconnected modem banks to promote higher scalability and flexibility. We formulate an optimization problem to efficiently manage traffic among these modem banks and balance the load. Additionally, we provide comparative numerical simulation results, considering end-to-end delay and packet loss analysis. The results illustrate that our proposed architecture maintains lower delays and packet loss even with higher traffic demands and smaller buffer sizes.