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Louis Collins

Alumni

Publications

Analyzing Alzheimer’s Disease Progression from Sequential Magnetic Resonance Imaging Scans Using Deep 3D Convolutional Neural Networks
Sumana Basu
Konrad Wagstyl
Azar Zandifar
Louis Collins
Adriana Romero
Doina Precup
Alzheimer’s is a progressive, neurodegenerative disease, that causes irreversible damage to the brain tissue. It impairs the ability to fo… (see more)rm and retrieve memory, and eventually disrupts the natural flow of life, by affecting the ability to carry out even day to day activities. The disease is typically diagnosed from the symptoms (Mini Mental State Examination, [8]), such as decline in cognitive abilities, visual and/or speech impairment, loss of memory, rather than the structural changes in the brain (biomarker) that causes it. But the pathological changes in the brain start decades before the manifestation of the symptoms [7]. Magnetic Resonance Imaging (MRI) is capable of capturing the complex changes in the brain, even if it is difficult for humans to extract those features from the low contrast, multi-dimensional MRIs [1]. There is a considerable amount of work on analyzing Alzheimer’s disease. However, the vast majority intends to predict the state of the disease at the current time step.
2017-12-31
(published)
www.semanticscholar.org