Joel Zylberberg

Timothy P. Lillicrap

2023-11-21

Journal of Neuroscience (published)

Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites

Colleen J Gillon

Jason E. Pina

Jérôme A. Lecoq

Ruweida Ahmed

Yazan N. Billeh

Shiella Caldejon

Peter Groblewski

Timothy M. Henley

India Kato

Eric Lee

Jennifer Luviano

Kyla Mace

Chelsea Nayan

Thuyanh V. Nguyen

Kat North

Jed Perkins

Sam Seid

Matthew T. Valley

Ali Williford

Timothy P. Lillicrap

Scientists have long conjectured that the neocortex learns patterns in sensory data to generate top-down predictions of upcoming stimuli. In… (see more) line with this conjecture, different responses to pattern-matching vs pattern-violating visual stimuli have been observed in both spiking and somatic calcium imaging data. However, it remains unknown whether these pattern-violation signals are different between the distal apical dendrites, which are heavily targeted by top-down signals, and the somata, where bottom-up information is primarily integrated. Furthermore, it is unknown how responses to pattern-violating stimuli evolve over time as an animal gains more experience with them. Here, we address these unanswered questions by analyzing responses of individual somata and dendritic branches of layer 2/3 and layer 5 pyramidal neurons tracked over multiple days in primary visual cortex of awake, behaving female and male mice. We use sequences of Gabor patches with patterns in their orientations to create pattern-matching and pattern-violating stimuli, and two-photon calcium imaging to record neuronal responses. Many neurons in both layers show large differences between their responses to pattern-matching and pattern-violating stimuli. Interestingly, these responses evolve in opposite directions in the somata and distal apical dendrites, with somata becoming less sensitive to pattern-violating stimuli and distal apical dendrites more sensitive. These differences between the somata and distal apical dendrites may be important for hierarchical computation of sensory predictions and learning, since these two compartments tend to receive bottom-up and top-down information, respectively.

2023-11-21

Journal of Neuroscience (published)

Responses to Pattern-Violating Visual Stimuli Evolve Differently Over Days in Somata and Distal Apical Dendrites

Colleen J Gillon

Jason E. Pina

Jérôme A. Lecoq

Ruweida Ahmed

Yazan N. Billeh

Shiella Caldejon

Peter Groblewski

Timothy M. Henley

India Kato

Eric Lee

Jennifer Luviano

Kyla Mace

Chelsea Nayan

Thuyanh V. Nguyen

Kat North

Jed Perkins

Sam Seid

Matthew T. Valley

Ali Williford

Timothy P. Lillicrap

Scientists have long conjectured that the neocortex learns patterns in sensory data to generate top-down predictions of upcoming stimuli. In… (see more) line with this conjecture, different responses to pattern-matching vs pattern-violating visual stimuli have been observed in both spiking and somatic calcium imaging data. However, it remains unknown whether these pattern-violation signals are different between the distal apical dendrites, which are heavily targeted by top-down signals, and the somata, where bottom-up information is primarily integrated. Furthermore, it is unknown how responses to pattern-violating stimuli evolve over time as an animal gains more experience with them. Here, we address these unanswered questions by analyzing responses of individual somata and dendritic branches of layer 2/3 and layer 5 pyramidal neurons tracked over multiple days in primary visual cortex of awake, behaving female and male mice. We use sequences of Gabor patches with patterns in their orientations to create pattern-matching and pattern-violating stimuli, and two-photon calcium imaging to record neuronal responses. Many neurons in both layers show large differences between their responses to pattern-matching and pattern-violating stimuli. Interestingly, these responses evolve in opposite directions in the somata and distal apical dendrites, with somata becoming less sensitive to pattern-violating stimuli and distal apical dendrites more sensitive. These differences between the somata and distal apical dendrites may be important for hierarchical computation of sensory predictions and learning, since these two compartments tend to receive bottom-up and top-down information, respectively.

2023-11-21

Journal of Neuroscience (published)

Responses of pyramidal cell somata and apical dendrites in mouse visual cortex over multiple days

Colleen J Gillon

Jérôme A. Lecoq

Jason E. Pina

Ruweida Ahmed

Yazan N. Billeh

Shiella Caldejon

Peter Groblewski

Timothy M. Henley

India Kato

Eric Lee

Jennifer Luviano

Kyla Mace

Chelsea Nayan

Thuyanh V. Nguyen

Kat North

Jed Perkins

Sam Seid

Matthew T. Valley

Ali Williford

Timothy P. Lillicrap

2023-05-17

Scientific Data (published)

Responses of pyramidal cell somata and apical dendrites in mouse visual cortex over multiple days

Colleen J Gillon

Jérôme A. Lecoq

Jason E. Pina

Ruweida Ahmed

Yazan N. Billeh

Shiella Caldejon

Peter Groblewski

Timothy M. Henley

India Kato

Eric Lee

Jennifer Luviano

Kyla Mace

Chelsea Nayan

Thuyanh V. Nguyen

Kat North

Jed Perkins

Sam Seid

Matthew T. Valley

Ali Williford

Timothy P. Lillicrap

2023-05-17

Scientific Data (published)

A deep learning framework for neuroscience

Timothy P. Lillicrap

Philippe Beaudoin

Yoshua Bengio

Rafal Bogacz

Amelia Christensen

Claudia Clopath

Rui Ponte Costa

Archy de Berker

Surya Ganguli

Colleen J Gillon

Danijar Hafner

Adam Kepecs

Nikolaus Kriegeskorte

Peter Latham

Grace W. Lindsay

Kenneth D. Miller

Richard Naud

Christopher C. Pack

Panayiota Poirazi … (see 12 more)

Pieter Roelfsema

João Sacramento

Andrew Saxe

Benjamin Scellier

Anna C. Schapiro

Walter Senn

Greg Wayne

Daniel Yamins

Friedemann Zenke

Denis Therien

Konrad Paul Kording

2019-10-28

Nature Neuroscience (published)