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Agnieszka Slowik

Alumni

Publications

Sex-specific lesion pattern of functional outcomes after stroke
Anna K. Bonkhoff
Martin Bretzner
Sungmin Hong
Markus D. Schirmer
Alexander L. Cohen
Robert W. Regenhardt
Kathleen Donahue
Marco Nardin
Adrian Dalca
Anne-Katrin Giese
Mark R. Etherton
Brandon L. Hancock
Steven J.T. Mocking
Elissa McIntosh
John Richard Attia
Oscar Benavente
S. Bevan
John W. Cole
Amanda Donatti
Christoph Griessenauer … (see 38 more)
Laura Heitsch
Lukas Holmegaard
Katarina Jood
Jordi Jimenez-Conde
Steven Kittner
Robin Lemmens
C. Levi
Caitrin W. McDonough
James Meschia
Chia-Ling Phuah
Arndt Rolfs
Stefan Ropele
Jonathan Rosand
Jaume Roquer
Tatjana Rundek
Ralph L. Sacco
Reinhold Schmidt
Pankaj Sharma
Agnieszka Slowik
Martin Söderholm
Alessandro Sousa
Tara M. Stanne
Daniel Strbian
Turgut Tatlisumak
Vincent Thijs
Achala Vagal
Johan Wasselius
Daniel Woo
Ramin Zand
P. McArdle
Bradford B. Worrall
Christina Jern
Arne G. Lindgren
Jane Maguire
M. Fox
Danilo Bzdok
Ona Wu
Natalia S. Rost
Abstract Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinicall… (see more)y relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric posterior circulation. We here determined whether these sex-specific brain manifestations also affect long-term outcomes. We relied on 822 acute ischaemic patients [age: 64.7 (15.0) years, 39% women] originating from the multi-centre MRI-GENIE study to model unfavourable outcomes (modified Rankin Scale >2) based on acute neuroimaging data in a Bayesian hierarchical framework. Lesions encompassing bilateral subcortical nuclei and left-lateralized regions in proximity to the insula explained outcomes across men and women (area under the curve = 0.81). A pattern of left-hemispheric posterior circulation brain regions, combining left hippocampus, precuneus, fusiform and lingual gyrus, occipital pole and latero-occipital cortex, showed a substantially higher relevance in explaining functional outcomes in women compared to men [mean difference of Bayesian posterior distributions (men – women) = −0.295 (90% highest posterior density interval = −0.556 to −0.068)]. Once validated in prospective studies, our findings may motivate a sex-specific approach to clinical stroke management and hold the promise of enhancing outcomes on a population level.
2022-02-02
Brain Communications (published)
doi.org
Sex-specific lesion pattern of functional outcomes after stroke
Anna K. Bonkhoff
Martin Bretzner
Sungmin Hong
Markus D. Schirmer
Alexander Cohen
Robert W. Regenhardt
Kathleen Donahue
Marco Nardin
Adrian Dalca
Anne-Katrin Giese
Mark R. Etherton
Brandon L. Hancock
Steven J.T. Mocking
Elissa McIntosh
John Attia
Oscar Benavente
Stephen Bevan
John W. Cole
Amanda Donatti
Christoph Griessenauer … (see 39 more)
Laura Heitsch
Lukas Holmegaard
Katarina Jood
Jordi Jimenez-Conde
Steven Kittner
Robin Lemmens
Christopher Levi
Caitrin W. McDonough
James Meschia
Chia-Ling Phuah
Arndt Rolfs
Stefan Ropele
Jonathan Rosand
Jaume Roquer
Tatjana Rundek
Ralph L. Sacco
Reinhold Schmidt
Pankaj Sharma
Agnieszka Slowik
Martin Soederholm
Alessandro Sousa
Tara M. Stanne
Daniel Strbian
Turgut Tatlisumak
Vincent Thijs
Achala Vagal
Johan Wasselius
Daniel Woo
Ramin Zand
Patrick McArdle
Bradford B. Worrall
Christina Jern
Arne G. Lindgren
Jane Maguire
Michael D. Fox
Danilo Bzdok
Ona Wu
Natalia S. Rost
Anna K. Martin Sungmin Markus D. Alexander Robert W. Kathleen L. Marco J. Adrian V. Anne-Katrin Mark R. Brandon L. Steven J. T. Elissa C. John Oscar R. Stephen John W. Amanda Christoph J. Laura Lukas Katarina Jordi Steven J. Robin Christopher R. Caitrin W. James F. Chia-Ling Arndt Stefan Jonathan Jaume Tatjana Ralph L. Reinhold Pankaj Agnieszka Martin Alessandro Tara M. Daniel Turgut Vincent Achala Johan Daniel Ramin Patrick F. Bradford B. Christina Arne G. Jane Michael D. Danilo Ona Natalia S. Bonkhoff
2022-02-02
Brain Communications (published)
doi.org