We use cookies to analyze the browsing and usage of our website and to personalize your experience. You can disable these technologies at any time, but this may limit certain functionalities of the site. Read our Privacy Policy for more information.
Setting cookies
You can enable and disable the types of cookies you wish to accept. However certain choices you make could affect the services offered on our sites (e.g. suggestions, personalised ads, etc.).
Essential cookies
These cookies are necessary for the operation of the site and cannot be deactivated. (Still active)
Analytics cookies
Do you accept the use of cookies to measure the audience of our sites?
Multimedia Player
Do you accept the use of cookies to display and allow you to watch the video content hosted by our partners (YouTube, etc.)?
Publications
Prediction of Disease Progression in Multiple Sclerosis Patients using Deep Learning Analysis of MRI Data
We present the first automatic end-to-end deep learning framework for the prediction of future patient disability progression (one year from… (see more) baseline) based on multi-modal brain Magnetic Resonance Images (MRI) of patients with Multiple Sclerosis (MS). The model uses parallel convolutional pathways, an idea introduced by the popular Inception net (Szegedy et al., 2015) and is trained and tested on two large proprietary, multi-scanner, multi-center, clinical trial datasets of patients with Relapsing-Remitting Multiple Sclerosis (RRMS). Experiments on 465 patients on the placebo arms of the trials indicate that the model can accurately predict future disease progression, measured by a sustained increase in the extended disability status scale (EDSS) score over time. Using only the multi-modal MRI provided at baseline, the model achieves an AUC of 0.66±0.055. However, when supplemental lesion label masks are provided as inputs as well, the AUC increases to 0.701± 0.027. Furthermore, we demonstrate that uncertainty estimates based on Monte Carlo dropout sample variance correlate with errors made by the model. Clinicians provided with the predictions computed by the model can therefore use the associated uncertainty estimates to assess which scans require further examination.
2019-05-24
International Conference on Medical Imaging with Deep Learning (published)
Machine learning promises methods that generalize well from finite labeled data. However, the brittleness of existing neural net approaches … (see more)is revealed by notable failures, such as the existence of adversarial examples that are misclassified despite being nearly identical to a training example, or the inability of recurrent sequence-processing nets to stay on track without teacher forcing. We introduce a method, which we refer to as \emph{state reification}, that involves modeling the distribution of hidden states over the training data and then projecting hidden states observed during testing toward this distribution. Our intuition is that if the network can remain in a familiar manifold of hidden space, subsequent layers of the net should be well trained to respond appropriately. We show that this state-reification method helps neural nets to generalize better, especially when labeled data are sparse, and also helps overcome the challenge of achieving robust generalization with adversarial training.
2019-05-24
Proceedings of the 36th International Conference on Machine Learning (published)
Robust and reliable stroke lesion segmentation is a crucial step toward employing lesion volume as an independent endpoint for randomized tr… (see more)ials. The aim of this work was to develop and evaluate a novel method to segment sub-acute ischemic stroke lesions from fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) datasets. After preprocessing of the datasets, a Bayesian technique based on Gabor textures extracted from the FLAIR signal intensities is utilized to generate a first estimate of the lesion segmentation. Using this initial segmentation, a customized voxel-level Markov random field model based on intensity as well as Gabor texture features is employed to refine the stroke lesion segmentation. The proposed method was developed and evaluated based on 151 multi-center datasets from three different databases using a leave-one-patient-out validation approach. The comparison of the automatically segmented stroke lesions with manual ground truth segmentation revealed an average Dice coefficient of 0.582, which is in the upper range of previously presented lesion segmentation methods using multi-modal MRI datasets. Furthermore, the results obtained by the proposed technique are superior compared to the results obtained by two methods based on convolutional neural networks and three phase level-sets, respectively, which performed best in the ISLES 2015 challenge using multi-modal imaging datasets. The results of the quantitative evaluation suggest that the proposed method leads to robust lesion segmentation results using FLAIR MRI datasets only as a follow-up sequence.
We establish geometric and topological properties of the space of value functions in finite state-action Markov decision processes. Our main… (see more) contribution is the characterization of the nature of its shape: a general polytope (Aigner et al., 2010). To demonstrate this result, we exhibit several properties of the structural relationship between policies and value functions including the line theorem, which shows that the value functions of policies constrained on all but one state describe a line segment. Finally, we use this novel perspective to introduce visualizations to enhance the understanding of the dynamics of reinforcement learning algorithms.
2019-05-24
Proceedings of the 36th International Conference on Machine Learning (published)
Entropy regularization is commonly used to improve policy optimization in reinforcement learning. It is believed to help with \emph{explorat… (see more)ion} by encouraging the selection of more stochastic policies. In this work, we analyze this claim using new visualizations of the optimization landscape based on randomly perturbing the loss function. We first show that even with access to the exact gradient, policy optimization is difficult due to the geometry of the objective function. Then, we qualitatively show that in some environments, a policy with higher entropy can make the optimization landscape smoother, thereby connecting local optima and enabling the use of larger learning rates. This paper presents new tools for understanding the optimization landscape, shows that policy entropy serves as a regularizer, and highlights the challenge of designing general-purpose policy optimization algorithms.
2019-05-24
Proceedings of the 36th International Conference on Machine Learning (published)
Unsupervised exploration and representation learning become increasingly important when learning in diverse and sparse environments. The inf… (see more)ormation-theoretic principle of empowerment formalizes an unsupervised exploration objective through an agent trying to maximize its influence on the future states of its environment. Previous approaches carry certain limitations in that they either do not employ closed-loop feedback or do not have an internal state. As a consequence, a privileged final state is taken as an influence measure, rather than the full trajectory. We provide a model-free method which takes into account the whole trajectory while still offering the benefits of option-based approaches. We successfully apply our approach to settings with large action spaces, where discovery of meaningful action sequences is particularly difficult.
Learning effective visuomotor policies for robots purely from data is challenging, but also appealing since a learning-based system should n… (see more)ot require manual tuning or calibration. In the case of a robot operating in a real environment the training process can be costly, time-consuming, and even dangerous since failures are common at the start of training. For this reason, it is desirable to be able to leverage simulation and off-policy data to the extent possible to train the robot. In this work, we introduce a robust framework that plans in simulation and transfers well to the real environment. Our model incorporates a gradient-descent based planning module, which, given the initial image and goal image, encodes the images to a lower dimensional latent state and plans a trajectory to reach the goal. The model, consisting of the encoder and planner modules, is first trained through a meta-learning strategy in simulation. We subsequently perform adversarial domain transfer on the encoder by using a bank of unlabelled but random images from the simulation and real environments to enable the encoder to map images from the real and simulated environments to a similarly distributed latent representation. By fine tuning the entire model (encoder + planner) with only a few real world expert demonstrations, we show successful planning performances in different navigation tasks.
2019-05-20
2019 International Conference on Robotics and Automation (ICRA) (published)
Despite the success of deep learning in speech recognition, multi-dialect speech recognition remains a difficult problem. Although dialect-s… (see more)pecific acoustic models are known to perform well in general, they are not easy to maintain when dialect-specific data is scarce and the number of dialects for each language is large. Therefore, a single unified acoustic model (AM) that generalizes well for many dialects has been in demand. In this paper, we propose a novel acoustic modeling technique for accurate multi-dialect speech recognition with a single AM. Our proposed AM is dynamically adapted based on both dialect information and its internal representation, which results in a highly adaptive AM for handling multiple dialects simultaneously. We also propose a simple but effective training method to deal with unseen dialects. The experimental results on large scale speech datasets show that the proposed AM outperforms all the previous ones, reducing word error rates (WERs) by 8.11% relative compared to a single all-dialects AM and by 7.31% relative compared to dialect-specific AMs.
2019-05-12
ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (published)
Characterization of the representations learned in intermediate layers of deep networks can provide valuable insight into the nature of a ta… (see more)sk and can guide the development of well-tailored learning strategies. Here we study convolutional neural network (CNN)-based acoustic models in the context of automatic speech recognition. Adapting a method proposed by [1], we measure the transferability of each layer between English, Dutch and German to assess their language-specificity. We observed three distinct regions of transferability: (1) the first two layers were entirely transferable between languages, (2) layers 2–8 were also highly transferable but we found some evidence of language specificity, (3) the subsequent fully connected layers were more language specific but could be successfully finetuned to the target language. To further probe the effect of weight freezing, we performed follow-up experiments using freeze-training [2]. Our results are consistent with the observation that CNNs converge ‘bottom up’ during training and demonstrate the benefit of freeze training, especially for transfer learning.
2019-05-12
IEEE International Conference on Acoustics, Speech, and Signal Processing (published)
Recent character and phoneme-based parametric TTS systems using deep learning have shown strong performance in natural speech generation. Ho… (see more)wever, the choice between character or phoneme input can create serious limitations for practical deployment, as direct control of pronunciation is crucial in certain cases. We demonstrate a simple method for combining multiple types of linguistic information in a single encoder, named representation mixing, enabling flexible choice between character, phoneme, or mixed representations during inference. Experiments and user studies on a public audiobook corpus show the efficacy of our approach.
2019-05-12
ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (published)
The availability of open-source software is playing a remarkable role in the popularization of speech recognition and deep learning. Kaldi, … (see more)for instance, is nowadays an established framework used to develop state-of-the-art speech recognizers. PyTorch is used to build neural networks with the Python language and has recently spawn tremendous interest within the machine learning community thanks to its simplicity and flexibility.The PyTorch-Kaldi project aims to bridge the gap between these popular toolkits, trying to inherit the efficiency of Kaldi and the flexibility of PyTorch. PyTorch-Kaldi is not only a simple interface between these software, but it embeds several useful features for developing modern speech recognizers. For instance, the code is specifically designed to naturally plug-in user-defined acoustic models. As an alternative, users can exploit several pre-implemented neural networks that can be customized using intuitive configuration files. PyTorch-Kaldi supports multiple feature and label streams as well as combinations of neural networks, enabling the use of complex neural architectures. The toolkit is publicly-released along with a rich documentation and is designed to properly work locally or on HPC clusters.Experiments, that are conducted on several datasets and tasks, show that PyTorch-Kaldi can effectively be used to develop modern state-of-the-art speech recognizers.
2019-05-12
ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (published)
