Mohammad Havaei

PRISM: High-Resolution & Precise Counterfactual Medical Image Generation using Language-guided Stable Diffusion

Developing reliable and generalizable deep learning systems for medical imaging faces significant obstacles due to spurious correlations, da… (see more)ta imbalances, and limited text annotations in datasets. Addressing these challenges requires architectures robust to the unique complexities posed by medical imaging data. The rapid advancements in vision-language foundation models within the natural image domain prompt the question of how they can be adapted for medical imaging tasks. In this work, we present PRISM, a framework that leverages foundation models to generate high-resolution, language-guided medical image counterfactuals using Stable Diffusion. Our approach demonstrates unprecedented precision in selectively modifying spurious correlations (the medical devices) and disease features, enabling the removal and addition of specific attributes while preserving other image characteristics. Through extensive evaluation, we show how PRISM advances counterfactual generation and enables the development of more robust downstream classifiers for clinically deployable solutions. To facilitate broader adoption and research, we make our code publicly available at https://github.com/Amarkr1/PRISM.

2025-03-01

arXiv (published)

PRISM: High-Resolution&Precise Counterfactual Medical Image Generation using Language-guided Stable Diffusion

Developing reliable and generalizable deep learning systems for medical imaging faces significant obstacles due to spurious correlations, da… (see more)ta imbalances, and limited text annotations in datasets. Addressing these challenges requires architectures robust to the unique complexities posed by medical imaging data. The rapid advancements in vision-language foundation models within the natural image domain prompt the question of how they can be adapted for medical imaging tasks. In this work, we present PRISM, a framework that leverages foundation models to generate high-resolution, language-guided medical image counterfactuals using Stable Diffusion. Our approach demonstrates unprecedented precision in selectively modifying spurious correlations (the medical devices) and disease features, enabling the removal and addition of specific attributes while preserving other image characteristics. Through extensive evaluation, we show how PRISM advances counterfactual generation and enables the development of more robust downstream classifiers for clinically deployable solutions. To facilitate broader adoption and research, we make our code publicly available at https://github.com/Amarkr1/PRISM.

2025-02-28

ArXiv (preprint)

arxiv.org

What Secrets Do Your Manifolds Hold? Understanding the Local Geometry of Generative Models

Ahmed Imtiaz Humayun

Ibtihel Amara

Candice Schumann

Cristina Nader Vasconcelos

Golnoosh Farnadi

Deepak Ramachandran

Negar Rostamzadeh

Junfeng He

Katherine Heller

2025-01-22

ICLR.cc/2025/Conference (poster)

What Secrets Do Your Manifolds Hold? Understanding the Local Geometry of Generative Models

Ahmed Imtiaz Humayun

Ibtihel Amara

Cristina Nader Vasconcelos

Deepak Ramachandran

Candice Schumann

Junfeng He

Katherine A Heller

Golnoosh Farnadi

Negar Rostamzadeh

Deep Generative Models are frequently used to learn continuous representations of complex data distributions using a finite number of sample… (see more)s. For any generative model, including pre-trained foundation models with GAN, Transformer or Diffusion architectures, generation performance can vary significantly based on which part of the learned data manifold is sampled. In this paper we study the post-training local geometry of the learned manifold and its relationship to generation outcomes for models ranging from toy settings to the latent decoder of the near state-of-the-art Stable Diffusion 1.4 Text-to-Image model. Building on the theory of continuous piecewise-linear (CPWL) generators, we characterize the local geometry in terms of three geometric descriptors - scaling (

2025-01-22

ICLR.cc/2025/Conference (poster)

Understanding the Local Geometry of Generative Model Manifolds

Ahmed Imtiaz Humayun

Candice Schumann

Deep generative models learn continuous representations of complex data manifolds using a finite number of samples during training. For a pr… (see more)e-trained generative model, the common way to evaluate the quality of the manifold representation learned, is by computing global metrics like Fr\'echet Inception Distance using a large number of generated and real samples. However, generative model performance is not uniform across the learned manifold, e.g., for \textit{foundation models} like Stable Diffusion generation performance can vary significantly based on the conditioning or initial noise vector being denoised. In this paper we study the relationship between the \textit{local geometry of the learned manifold} and downstream generation. Based on the theory of continuous piecewise-linear (CPWL) generators, we use three geometric descriptors - scaling (

2024-08-15

ArXiv (preprint)

arxiv.org

Position: Cracking the Code of Cascading Disparity Towards Marginalized Communities

Golnoosh Farnadi

Negar Rostamzadeh

2024-07-08

Proceedings of the 41st International Conference on Machine Learning (published)

On The Local Geometry of Deep Generative Manifolds

Ahmed Imtiaz Humayun

Candice Schumann

In this paper, we study theoretically inspired local geometric descriptors of the data manifolds approximated by pre-trained generative mode… (see more)ls. The descriptors – local scaling (ψ), local rank (ν), and local complexity (δ) — characterize the uncertainty, dimensionality, and smoothness on the learned manifold, using only the network weights and architecture. We investigate and emphasize their critical role in understanding generative models. Our analysis reveals that the local geometry is intricately linked to the quality and diversity of generated outputs. Additionally, we see that the geometric properties are distinct for out-of-distribution (OOD) inputs as well as for prompts memorized by Stable Diffusion, showing the possible application of our proposed descriptors for downstream detection and assessment of pre-trained generative models.

2024-06-17

ICML.cc/2024/Workshop/GRaM (published)

DeCoDEx: Confounder Detector Guidance for Improved Diffusion-based Counterfactual Explanations

Deep learning classifiers are prone to latching onto dominant confounders present in a dataset rather than on the causal markers associated … (see more)with the target class, leading to poor generalization and biased predictions. Although explainability via counterfactual image generation has been successful at exposing the problem, bias mitigation strategies that permit accurate explainability in the presence of dominant and diverse artifacts remain unsolved. In this work, we propose the DeCoDEx framework and show how an external, pre-trained binary artifact detector can be leveraged during inference to guide a diffusion-based counterfactual image generator towards accurate explainability. Experiments on the CheXpert dataset, using both synthetic artifacts and real visual artifacts (support devices), show that the proposed method successfully synthesizes the counterfactual images that change the causal pathology markers associated with Pleural Effusion while preserving or ignoring the visual artifacts. Augmentation of ERM and Group-DRO classifiers with the DeCoDEx generated images substantially improves the results across underrepresented groups that are out of distribution for each class. The code is made publicly available at https://github.com/NimaFathi/DeCoDEx.

2024-02-13

MIDL.io/2024/Conference/Submission (unknown)

DeCoDEx: Confounder Detector Guidance for Improved Diffusion-based Counterfactual Explanations

Deep learning classifiers are prone to latching onto dominant confounders present in a dataset rather than on the causal markers associated … (see more)with the target class, leading to poor generalization and biased predictions. Although explainability via counterfactual image generation has been successful at exposing the problem, bias mitigation strategies that permit accurate explainability in the presence of dominant and diverse artifacts remain unsolved. In this work, we propose the DeCoDEx framework and show how an external, pre-trained binary artifact detector can be leveraged during inference to guide a diffusion-based counterfactual image generator towards accurate explainability. Experiments on the CheXpert dataset, using both synthetic artifacts and real visual artifacts (support devices), show that the proposed method successfully synthesizes the counterfactual images that change the causal pathology markers associated with Pleural Effusion while preserving or ignoring the visual artifacts. Augmentation of ERM and Group-DRO classifiers with the DeCoDEx generated images substantially improves the results across underrepresented groups that are out of distribution for each class. The code is made publicly available at https://github.com/NimaFathi/DeCoDEx.

2024-01-01

MIDL (published)

Source-free Domain Adaptation Requires Penalized Diversity

Laya Rafiee Sevyeri

Ivaxi Sheth

Farhood Farahnak

Alexandre See

Samira Ebrahimi Kahou

Thomas Fevens

While neural networks are capable of achieving human-like performance in many tasks such as image classification, the impressive performance… (see more) of each model is limited to its own dataset. Source-free domain adaptation (SFDA) was introduced to address knowledge transfer between different domains in the absence of source data, thus, increasing data privacy. Diversity in representation space can be vital to a model`s adaptability in varied and difficult domains. In unsupervised SFDA, the diversity is limited to learning a single hypothesis on the source or learning multiple hypotheses with a shared feature extractor. Motivated by the improved predictive performance of ensembles, we propose a novel unsupervised SFDA algorithm that promotes representational diversity through the use of separate feature extractors with Distinct Backbone Architectures (DBA). Although diversity in feature space is increased, the unconstrained mutual information (MI) maximization may potentially introduce amplification of weak hypotheses. Thus we introduce the Weak Hypothesis Penalization (WHP) regularizer as a mitigation strategy. Our work proposes Penalized Diversity (PD) where the synergy of DBA and WHP is applied to unsupervised source-free domain adaptation for covariate shift. In addition, PD is augmented with a weighted MI maximization objective for label distribution shift. Empirical results on natural, synthetic, and medical domains demonstrate the effectiveness of PD under different distributional shifts.

2023-04-06

ArXiv (preprint)

arxiv.org

Learning from uncertain concepts via test time interventions

Ivaxi Sheth

Aamer Abdul Rahman

Laya Rafiee Sevyeri

Samira Ebrahimi Kahou

With neural networks applied to safety-critical applications, it has become increasingly important to understand the defining features of de… (see more)cision-making. Therefore, the need to uncover the black boxes to rational representational space of these neural networks is apparent. Concept bottleneck model (CBM) encourages interpretability by predicting human-understandable concepts. They predict concepts from input images and then labels from concepts. Test time intervention, a salient feature of CBM, allows for human-model interactions. However, these interactions are prone to information leakage and can often be ineffective inappropriate communication with humans. We propose a novel uncertainty based strategy, \emph{SIUL: Single Interventional Uncertainty Learning} to select the interventions. Additionally, we empirically test the robustness of CBM and the effect of SIUL interventions under adversarial attack and distributional shift. Using SIUL, we observe that the interventions suggested lead to meaningful corrections along with mitigation of concept leakage. Extensive experiments on three vision datasets along with a histopathology dataset validate the effectiveness of our interventional learning.

2022-11-20

NeurIPS.cc/2022/Workshop/TSRML (accepted)