Publications

Structured Conditional Continuous Normalizing Flows for Efficient Amortized Inference in Graphical Models
Christian Dietrich Weilbach
Boyan Beronov
William Harvey
We exploit minimally faithful inversion of graphical model structures to specify sparse continuous normalizing flows (CNFs) for amortized i… (voir plus)nference. We find that the sparsity of this factorization can be exploited to reduce the numbers of parameters in the neural network, adaptive integration steps of the flow, and consequently FLOPs at both training and inference time without decreasing performance in comparison to unconstrained flows. By expressing the structure inversion as a compilation pass in a probabilistic programming language, we are able to apply it in a novel way to models as complex as convolutional neural networks. Furthermore, we extend the training objective for CNFs in the context of inference amortization to the symmetric Kullback-Leibler divergence, and demonstrate its theoretical and practical advantages.
Structured Conditional Continuous Normalizing Flows for Efficient Amortized Inference in Graphical Models
Christian Dietrich Weilbach
Boyan Beronov
William Harvey
We exploit minimally faithful inversion of graphical model structures to specify sparse continuous normalizing flows (CNFs) for amortized i… (voir plus)nference. We find that the sparsity of this factorization can be exploited to reduce the numbers of parameters in the neural network, adaptive integration steps of the flow, and consequently FLOPs at both training and inference time without decreasing performance in comparison to unconstrained flows. By expressing the structure inversion as a compilation pass in a probabilistic programming language, we are able to apply it in a novel way to models as complex as convolutional neural networks. Furthermore, we extend the training objective for CNFs in the context of inference amortization to the symmetric Kullback-Leibler divergence, and demonstrate its theoretical and practical advantages.
Synbols: Probing Learning Algorithms with Synthetic Datasets
Alexandre Lacoste
Pau Rodr'iguez
Frédéric Branchaud-charron
Parmida Atighehchian
Massimo Caccia
Issam Hadj Laradji
Matt P. Craddock
David Vazquez
Tensorized Random Projections
Beheshteh T. Rakhshan
On the Effectiveness of Two-Step Learning for Latent-Variable Models
Latent-variable generative models offer a principled solution for modeling and sampling from complex probability distributions. Implementing… (voir plus) a joint training objective with a complex prior, however, can be a tedious task, as one is typically required to derive and code a specific cost function for each new type of prior distribution. In this work, we propose a general framework for learning latent variable generative models in a two-step fashion. In the first step of the framework, we train an autoencoder, and in the second step we fit a prior model on the resulting latent distribution. This two-step approach offers a convenient alternative to joint training, as it allows for a straightforward combination of existing models without the hustle of deriving new cost functions, and the need for coding the joint training objectives. Through a set of experiments, we demonstrate that two-step learning results in performances similar to joint training, and in some cases even results in more accurate modeling.
On the interplay between noise and curvature and its effect on optimization and generalization
Valentin Thomas
Fabian Pedregosa
Bart van Merriënboer
Pierre-Antoine Manzagol
The speed at which one can minimize an expected loss using stochastic methods depends on two properties: the curvature of the loss and the v… (voir plus)ariance of the gradients. While most previous works focus on one or the other of these properties, we explore how their interaction affects optimization speed. Further, as the ultimate goal is good generalization performance, we clarify how both curvature and noise are relevant to properly estimate the generalization gap. Realizing that the limitations of some existing works stems from a confusion between these matrices, we also clarify the distinction between the Fisher matrix, the Hessian, and the covariance matrix of the gradients.
On the Systematicity of Probing Contextualized Word Representations: The Case of Hypernymy in BERT.
Abhilasha Ravichander
Eduard Hovy
Kaheer Suleman
Adam Trischler
A Tight and Unified Analysis of Gradient-Based Methods for a Whole Spectrum of Differentiable Games
We consider differentiable games where the goal is to find a Nash equilibrium. The machine learning community has recently started using v… (voir plus)ariants of the gradient method ( GD ). Prime examples are extragradient ( EG ), the optimistic gradient method ( OG ) and consensus optimization ( CO ), which enjoy linear convergence in cases like bilinear games, where the standard GD fails. The full bene-fits of theses relatively new methods are not known as there is no unified analysis for both strongly monotone and bilinear games. We provide new analyses of the EG ’s local and global convergence properties and use is to get a tighter global convergence rate for OG and CO . Our analysis covers the whole range of settings between bilinear and strongly monotone games. It reveals that these methods converges via different mechanisms at these extremes; in between, it exploits the most favorable mechanism for the given problem. We then prove that EG achieves the optimal rate for a wide class of algorithms with any number of extrapolations. Our tight analysis of EG ’s convergence rate in games shows that, unlike in convex minimization, EG may be much faster than GD .
A Tight and Unified Analysis of Gradient-Based Methods for a Whole Spectrum of Differentiable Games.
Title : Differential functional neural circuitry behind autism subtypes with marked imbalance between social-communicative and restricted repetitive behavior symptom domains
Natasha Bertelsen
Isotta Landi
Richard A.I. Bethlehem
Jakob Seidlitz
Elena
Maria Busuoli
Veronica Mandelli
Eleonora Satta
Stavros Trakoshis
Bonnie Auyeung
Prantik Kundu
Eva Loth
Sarah Baumeister
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Tony Charman
Sarah Durston
Christine Ecker … (voir 22 de plus)
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Luke Mason
-. AndreasMeyer
Lindenberg
Carolin
Moessnang
Marianne
Oldehinkel
Antonio
Persico
Julian
Tillmann
Steven C. R. Williams
Will Spooren
Declan Murphy
Katherine Jan
Buitelaar
Simon Baron-Cohen
Meng-Chuan Lai
Michael V. Lombardo
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly … (voir plus)differ within and between individuals and is underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (96-98%) out-of-sample SC=RRB, SC>RRB, and RRB>SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n=509), we find replicable somatomotor-perisylvian hypoconnectivity in the SC>RRB subtype versus a typically-developing (TD) comparison group. In contrast, replicable motor-anterior salience hyperconnectivity is apparent in the SC=RRB subtype versus TD. Autism-associated genes affecting astrocytes, excitatory, and inhibitory neurons are highly expressed specifically within SC>RRB hypoconnected networks, but not SC=RRB hyperconnected networks. SC-RRB balance subtypes may indicate different paths individuals take from genome, neural circuitry, to the clinical phenotype. (CIMH). Procedures were undertaken to optimize the MRI sequences for the best scanner-specific options, and phantoms and travelling heads were employed to assure standardization and quality assurance of the multisite image-acquisition 20 . Structural images were obtained using a 5.5 minute MPRAGE sequence (TR=2300ms, TE=2.93ms, T1=900ms, voxels size=1.1x1.1x1.2mm, flip angle=9°, matrix size=256x256, FOV=270mm, 176 slices). An eight-to-ten minute resting-state fMRI (rsfMRI) scan was acquired using a multi-echo planar imaging (ME-EPI) sequence 65,66 ; TR=2300ms, TE~12ms, 31ms, and 48ms (slight variations are present across centers), flip angle=80°, matrix size=64x64, (UMCU), 215 (KCL, CIMH), 265 (RUMC, UCAM). were to relax, with eyes open and fixate on a cross presented on the screen for the duration of the rsfMRI scan.
Towards Queryable and Traceable Domain Models
Rijul Saini
Gunter Mussbacher
Jörg Kienzle
Model-Driven Software Engineering encompasses various modelling formalisms for supporting software development. One such formalism is domain… (voir plus) modelling which bridges the gap between requirements expressed in natural language and analyzable and more concise domain models expressed in class diagrams. Due to the lack of modelling skills among novice modellers and time constraints in industrial projects, it is often not possible to build an accurate domain model manually. To address this challenge, we aim to develop an approach to extract domain models from problem descriptions written in natural language by combining rules based on natural language processing with machine learning. As a first step, we report on an automated and tool-supported approach with an accuracy of extracted domain models higher than existing approaches. In addition, the approach generates trace links for each model element of a domain model. The trace links enable novice modellers to execute queries on the extracted domain models to gain insights into the modelling decisions taken for improving their modelling skills. Furthermore, to evaluate our approach, we propose a novel comparison metric and discuss our experimental design. Finally, we present a research agenda detailing research directions and discuss corresponding challenges.
Towards robust and replicable sex differences in the intrinsic brain 1 function of autism 2 3
Dorothea L. Floris
José O. A. Filho
Meng-Chuan Lai
Steve
Giavasis
Marianne Oldehinkel
Maarten Mennes
Tony Charman
Julian
Tillmann
Christine Ecker
Flavio Dell’Acqua
Tobias Banaschewski
Carolin Moessnang
Simon Baron-Cohen
Sarah
Durston
Eva Loth
Declan Murphy … (voir 4 de plus)
Jan K. Buitelaar
Christian Beckmann
Michael P. Milham
A. Martino
84 Background: Marked sex differences in autism prevalence accentuate the need to understand 85 the role of biological sex-related factors i… (voir plus)n autism. Efforts to unravel sex differences in the 86 brain organization of autism have, however, been challenged by the limited availability of 87 female data. Methods: We addressed this gap by using a large sample of males and females 88 with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 89 females; NT: 409 males, 166 females; 7-18 years). Discovery analyses examined main effects 90 of diagnosis, sex and their interaction across five resting-state fMRI (R-fMRI) metrics 91 (voxel-level Z > 3.1, cluster-level P 0.01, gaussian random field corrected). Secondary 92 analyses assessed the robustness of the results to different pre-processing approaches and 93 their replicability in two independent samples: the EU-AIMS Longitudinal European Autism 94 Project (LEAP) and the Gender Explorations of Neurogenetics and Development to Advance 95 Autism Research (GENDAAR). Results: Discovery analyses in ABIDE revealed significant 96 main effects across the intrinsic functional connectivity (iFC) of the posterior cingulate 97 cortex, regional homogeneity and voxel-mirrored homotopic connectivity (VMHC) in several 98 cortical regions, largely converging in the default network midline. Sex-by-diagnosis 99 interactions were confined to the dorsolateral occipital cortex, with reduced VMHC in 100 females with autism. All findings were robust to different pre-processing steps. Replicability 101 in independent samples varied by R-fMRI measures and effects with the targeted sex-by102 diagnosis interaction being replicated in the larger of the two replication samples – EU-AIMS 103 LEAP. Limitations: Given the lack of a priori harmonization among the discovery and 104 replication datasets available to date, sample-related variation remained and may have 105 affected replicability. Conclusions: Atypical cross-hemispheric interactions are 106 neurobiologically relevant to autism. They likely result from the combination of sex107