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Publications
Debiasing Counterfactuals in the Presence of Spurious Correlations
Deep learning models can perform well in complex medical imaging classification tasks, even when basing their conclusions on spurious correl… (see more)ations (i.e. confounders), should they be prevalent in the training dataset, rather than on the causal image markers of interest. This would thereby limit their ability to generalize across the population. Explainability based on counterfactual image generation can be used to expose the confounders but does not provide a strategy to mitigate the bias. In this work, we introduce the first end-to-end training framework that integrates both (i) popular debiasing classifiers (e.g. distributionally robust optimization (DRO)) to avoid latching onto the spurious correlations and (ii) counterfactual image generation to unveil generalizable imaging markers of relevance to the task. Additionally, we propose a novel metric, Spurious Correlation Latching Score (SCLS), to quantify the extent of the classifier reliance on the spurious correlation as exposed by the counterfactual images. Through comprehensive experiments on two public datasets (with the simulated and real visual artifacts), we demonstrate that the debiasing method: (i) learns generalizable markers across the population, and (ii) successfully ignores spurious correlations and focuses on the underlying disease pathology.
2023-10-09
Clinical Image-Based Procedures, Fairness of AI in Medical Imaging, and Ethical and Philosophical Issues in Medical Imaging (published)
Image-based precision medicine aims to personalize treatment decisions based on an individual's unique imaging features so as to improve the… (see more)ir clinical outcome. Machine learning frameworks that integrate uncertainty estimation as part of their treatment recommendations would be safer and more reliable. However, little work has been done in adapting uncertainty estimation techniques and validation metrics for precision medicine. In this paper, we use Bayesian deep learning for estimating the posterior distribution over factual and counterfactual outcomes on several treatments. This allows for estimating the uncertainty for each treatment option and for the individual treatment effects (ITE) between any two treatments. We train and evaluate this model to predict future new and enlarging T2 lesion counts on a large, multi-center dataset of MR brain images of patients with multiple sclerosis, exposed to several treatments during randomized controlled trials. We evaluate the correlation of the uncertainty estimate with the factual error, and, given the lack of ground truth counterfactual outcomes, demonstrate how uncertainty for the ITE prediction relates to bounds on the ITE error. Lastly, we demonstrate how knowledge of uncertainty could modify clinical decision-making to improve individual patient and clinical trial outcomes.
In this study, we highlight the importance of enhancing the quality of pretraining data in multilingual language models.
Existing web crawl… (see more)s have demonstrated quality issues, particularly in the context of low-resource languages.
Consequently, we introduce a new multilingual pretraining corpus for
Accelerating material discovery holds the potential to greatly help mitigate the climate crisis. Discovering new solid-state materials such … (see more)as electrocatalysts, super-ionic conductors or photovoltaic materials can have a crucial impact, for instance, in improving the efficiency of renewable energy production and storage. In this paper, we introduce Crystal-GFN, a generative model of crystal structures that sequentially samples structural properties of crystalline materials, namely the space group, composition and lattice parameters. This domain-inspired approach enables the flexible incorporation of physical and structural hard constraints, as well as the use of any available predictive model of a desired physicochemical property as an objective function. To design stable materials, one must target the candidates with the lowest formation energy. Here, we use as objective the formation energy per atom of a crystal structure predicted by a new proxy machine learning model trained on MatBench. The results demonstrate that Crystal-GFN is able to sample highly diverse crystals with low (median -3.1 eV/atom) predicted formation energy.
In the age of artificial intelligence, the role of large language models (LLMs) is becoming increasingly central. Despite their growing prev… (see more)alence, their capacity to consolidate knowledge from different training documents—a crucial ability in numerous applications—remains unexplored. This paper presents the first study examining the capability of LLMs to effectively combine such information within their parameter space. We introduce EpiK-Eval, a novel question-answering benchmark tailored to evaluate LLMs' proficiency in formulating a coherent and consistent knowledge representation from segmented narratives. Evaluations across various LLMs reveal significant weaknesses in this domain. We contend that these shortcomings stem from the intrinsic nature of prevailing training objectives. Consequently, we advocate for refining the approach towards knowledge consolidation, as it harbors the potential to dramatically improve their overall effectiveness and performance. The findings from this study offer insights for developing more robust and reliable LLMs. Our code and benchmark are available at https://github.com/chandar-lab/EpiK-Eval
Multi-modal open-domain question answering typically requires evidence retrieval from databases across diverse modalities, such as images, t… (see more)ables, passages, etc. Even Large Language Models (LLMs) like GPT-4 fall short in this task. To enable LLMs to tackle the task in a zero-shot manner, we introduce MoqaGPT, a straightforward and flexible framework. Using a divide-and-conquer strategy that bypasses intricate multi-modality ranking, our framework can accommodate new modalities and seamlessly transition to new models for the task. Built upon LLMs, MoqaGPT retrieves and extracts answers from each modality separately, then fuses this multi-modal information using LLMs to produce a final answer. Our methodology boosts performance on the MMCoQA dataset, improving F1 by +37.91 points and EM by +34.07 points over the supervised baseline. On the MultiModalQA dataset, MoqaGPT surpasses the zero-shot baseline, improving F1 by 9.5 points and EM by 10.1 points, and significantly closes the gap with supervised methods. Our codebase is available at https://github.com/lezhang7/MOQAGPT.