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Stéphanie Larocque

Alumni

Publications

BigBrain 3D atlas of cortical layers: Cortical and laminar thickness gradients diverge in sensory and motor cortices
Konrad Wagstyl
Stéphanie Larocque
Guillem Cucurull
Claude Lepage
Joseph Paul Cohen
Sebastian Bludau
Nicola Palomero-Gallagher
Lindsay B. Lewis
Thomas Funck
Hannah Spitzer
Timo Dickscheid
Paul C. Fletcher
Adriana Romero
Karl Zilles
Katrin Amunts
Yoshua Bengio
Alan C. Evans
Histological atlases of the cerebral cortex, such as those made famous by Brodmann and von Economo, are invaluable for understanding human b… (see more)rain microstructure and its relationship with functional organization in the brain. However, these existing atlases are limited to small numbers of manually annotated samples from a single cerebral hemisphere, measured from 2D histological sections. We present the first whole-brain quantitative 3D laminar atlas of the human cerebral cortex. This atlas was derived from a 3D histological model of the human brain at 20 micron isotropic resolution (BigBrain), using a convolutional neural network to segment, automatically, the cortical layers in both hemispheres. Our approach overcomes many of the historical challenges with measurement of histological thickness in 2D and the resultant laminar atlas provides an unprecedented level of precision and detail. We utilized this BigBrain cortical atlas to test whether previously reported thickness gradients, as measured by MRI in sensory and motor processing cortices, were present in a histological atlas of cortical thickness, and which cortical layers were contributing to these gradients. Cortical thickness increased across sensory processing hierarchies, primarily driven by layers III, V and VI. In contrast, fronto-motor cortices showed the opposite pattern, with decreases in total and pyramidal layer thickness. These findings illustrate how this laminar atlas will provide a link between single-neuron morphology, mesoscale cortical layering, macroscopic cortical thickness and, ultimately, functional neuroanatomy.
2019-03-16
bioRxiv (preprint)
doi.org
BigBrain: 1D convolutional neural networks for automated sementation of cortical layers
Konrad Wagstyl
Claude Lepage
Karl Zilles
Sebastian Bludau
G. Cucurul
Alan C. Evans
Paul C Fletcher
Adriana Romero
Joseph Paul Cohen
Stéphanie Larocque
Thomas Funck
Katrin Amunts
Yoshua Bengio
2017-12-31
(published)
www.semanticscholar.org