Mila’s AI for Climate Studio aims to bridge the gap between technology and impact to unlock the potential of AI in tackling the climate crisis rapidly and on a massive scale.
The program recently published its first policy brief, titled "Policy Considerations at the Intersection of Quantum Technologies and Artificial Intelligence," authored by Padmapriya Mohan.
Hugo Larochelle appointed Scientific Director of Mila
An adjunct professor at the Université de Montréal and former head of Google's AI lab in Montréal, Hugo Larochelle is a pioneer in deep learning and one of Canada’s most respected researchers.
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Spatial transcriptomics has revolutionized our ability to characterize tissues and diseases by contextualizing gene expression with spatial … (see more)organization. Available methods require researchers to either train a model using histology-based annotations or use annotation-free clustering approaches to uncover spatial domains. However, few methods provide researchers with a way to jointly analyze spatial data from both annotation-free and annotation-guided perspectives using consistent inductive biases and levels of interpretability. A single framework with consistent inductive biases ensures coherence and transferability across tasks, reducing the risks of conflicting assumptions. To this end, we propose the Spatial Topic Model (SpaTM), a topic-modeling framework capable of annotation-guided and annotation-free analysis of spatial transcriptomics data. SpaTM can be used to learn gene programs that represent histology-based annotations while providing researchers with the ability to infer spatial domains with an annotation-free approach if manual annotations are limited or noisy. We demonstrate SpaTM’s interpretability with its use of topic mixtures to represent cell states and transcriptional programs and how its intuitive framework facilitates the integration of annotation-guided and annotation-free analyses of spatial data with downstream analyses such as cell type deconvolution. Finally, we demonstrate how both approaches can be used to extend the analysis of large-scale snRNA-seq atlases with the inference of cell proximity and spatial annotations in human brains with Major Depressive Disorder.