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Elliot Layne

elliot.layne@mila.quebec
Doctorat - McGill University
Superviseur⋅e principal⋅e
Mathieu Blanchette
Google Scholar

Publications

Multi-ancestry polygenic risk scores using phylogenetic regularization
Elliot Layne
Shadi Zabad
Yue Li
Mathieu Blanchette
2024-02-17
bioRxiv (prépublication)
doi.org
PhyloGFN: Phylogenetic inference with generative flow networks
Ming Yang Zhou
Zichao Yan
Elliot Layne
Nikolay Malkin
Dinghuai Zhang
Moksh J. Jain
Mathieu Blanchette
Yoshua Bengio
2024-01-16
ICLR.cc/2024/Conference (poster)
doi.org
openreview.net
Leveraging Structure Between Environments: Phylogenetic Regularization Incentivizes Disentangled Representations
Elliot Layne
Jason Hartford
Sébastien Lachapelle
Mathieu Blanchette
Dhanya Sridhar
Recently, learning invariant predictors across varying environments has been shown to improve the generalization of supervised learning meth… (voir plus)ods. This line of investigation holds great potential for application to biological problem settings, where data is often naturally heterogeneous. Biological samples often originate from different distributions, or environments. However, in biological contexts, the standard "invariant prediction" setting may not completely fit: the optimal predictor may in fact vary across biological environments. There also exists strong domain knowledge about the relationships between environments, such as the evolutionary history of a set of species, or the differentiation process of cell types. Most work on generic invariant predictors have not assumed the existence of structured relationships between environments. However, this prior knowledge about environments themselves has already been shown to improve prediction through a particular form of regularization applied when learning a set of predictors. In this work, we empirically evaluate whether a regularization strategy that exploits environment-based prior information can be used to learn representations that better disentangle causal factors that generate observed data. We find evidence that these methods do in fact improve the disentanglement of latent embeddings. We also show a setting where these methods can leverage phylogenetic information to estimate the number of latent causal features.
2022-07-09
auai.org/UAI/2022/Workshop/CRL (poster)
doi.org
openreview.net