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Inspiring the development of artificial intelligence for the benefit of all 

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Located in the heart of Quebec’s AI ecosystem, Mila is a community of more than 1,200 researchers specializing in machine learning and dedicated to scientific excellence and innovation.

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News

01 May 2025
Follow Mila researchers at AISTATS 2025
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29 Apr 2025
Mila Techaide 2025 Raises over $110,000 in Donations
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24 Apr 2025
Innovasea Partners with Mila to Advance AI Innovation in the Blue Economy
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Faculty 

Founded in 1993 by Professor Yoshua Bengio, Mila today brings together over 140 professors affiliated with Université de Montréal, McGill University, Polytechnique Montréal and HEC Montréal. Mila also welcomes professors from Université Laval, Université de Sherbrooke, École de technologie supérieure (ÉTS) and Concordia University. 

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Latest Publications

Evaluating machine learning-driven intrusion detection systems in IoT: Performance and energy consumption
Saeid Jamshidi
Kawser Wazed Nafi
Amin Nikanjam
Foutse Khomh
2025-06-01
Computers & Industrial Engineering (published)
doi.org
arxiv.org
Generative AI: Hype, Hope, and Responsible Use in Science and Everyday Life
Doina Precup
2025-05-01
Biological Psychiatry (published)
doi.org
What makes a good public EV charging station? A revealed preference study
Steven Lamontagne
Margarida Carvalho
Emma Frejinger
Ribal Atallah
2025-04-24
ArXiv (preprint)
arxiv.org
arxiv.org
A flaw in using pre-trained pLLMs in protein-protein interaction inference models
Joseph Szymborski
Amin Emad
With the growing pervasiveness of pre-trained protein large language models (pLLMs), pLLM-based methods are increasingly being put forward f… (see more)or the protein-protein interaction (PPI) inference task. Here, we identify and confirm that existing pre-trained pLLMs are a source of data leakage for the downstream PPI task. We characterize the extent of the data leakage problem by training and comparing small and efficient pLLMs on a dataset that controls for data leakage (“strict”) with one that does not (“non-strict”). While data leakage from pre-trained pLLMs cause measurable inflation of testing scores, we find that this does not necessarily extend to other, non-paired biological tasks such as protein keyword annotation. Further, we find no connection between the context-lengths of pLLMs and the performance of pLLM-based PPI inference methods on proteins with sequence lengths that surpass it. Furthermore, we show that pLLM-based and non-pLLM-based models fail to generalize in tasks such as prediction of the human-SARS-CoV-2 PPIs or the effect of point mutations on binding-affinities. This study demonstrates the importance of extending existing protocols for the evaluation of pLLM-based models applied to paired biological datasets and identifies areas of weakness of current pLLM models.
2025-04-23
bioRxiv (preprint)
doi.org
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AI for Humanity

Socially responsible and beneficial development of AI is a fundamental component of Mila’s mission. As a leader in the field, we wish to contribute to social dialogue and the development of applications that will benefit society.

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